02764nas a2200481   4500000000100000008004100001260001300042653001500055653001000070653000900080653002400089653001000113653002000123653002000143653002800163653001800191653003800209653001100247653001600258653001100274653002500285653002500310653000900335653001600344653002500360653001600385653002600401100001600427700001400443700001600457700001500473700001300488700002500501700002400526700002000550700001600570245022100586856004100807300001000848490000700858520140300865022001402268       1993                            d  c1993 Jun10aAdolescent10aAdult10aAged10aAntigens, Bacterial10aChild10aContact Tracing10aCross Reactions10aCross-Sectional Studies10aDisaccharides10aEnzyme-Linked Immunosorbent Assay10aFemale10aGlycolipids10aHumans10aLeprosy, lepromatous10aLeprosy, Tuberculoid10aMale10aMiddle Aged10aMycobacterium leprae10aPhilippines10aSerum Albumin, Bovine1 aCellona R V1 aWalsh G P1 aFajardo T T1 aAbalos R M1 aCruz E C1 aGuido-Villahermosa L1 aFelicio-Balagon M V1 aSteenbergen G J1 aDouglas J T00aCross-sectional assessment of ELISA reactivity in leprosy patients, contacts, and normal population using the semisynthetic antigen natural disaccharide octyl bovine serum albumin (ND-O-BSA) in Cebu, The Philippines.  uhttp://ila.ilsl.br/pdfs/v61n2a02.pdf  a192-80 v613 a<p>An indirect enzyme-linked immunosorbent assay (ELISA) using natural disaccharide octyl bovine serum albumin (ND-O-BSA) as antigen was used in testing leprosy patients, contacts and a normal population in Cebu, The Philippines, from 1985 to 1989. A total of 1413 persons were studied. The results suggested that ELISA reactivity and the bacterial index (BI) correlate in a general way. In multibacillary (MB) leprosy, positivity ranges from 54.2% to 92.3% among patients with a BI of &lt; 2+ to &gt; 4+ on the Ridley scale, with an overall average of 84.5%. Paucibacillary (PB) leprosy patients have a low degree of reactivity, with only 15.0% ELISA positive. The test is more efficient in detecting MB than PB leprosy. The contacts of MB leprosy showed 6.5% positivity; contacts of PB leprosy, 7.0% positivity. The normal population showed 1.7% positive ELISA or 17 per thousand population, which is very much less than that of the household contacts. However, because the normal population is a much larger population than the household contact population in a community, more new leprosy cases would emanate from it. Leprosy workers are concerned about the transmission of the disease to household contacts. However, for the reason stated above, we should be more concerned with the silent spread of the disease to the normal population in the community.(ABSTRACT TRUNCATED AT 250 WORDS)</p>
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