01890nas a2200241   4500000000100000008004100001260004100042653001700083653002400100100001400124700001300138700002500151700002000176700001500196700001500211700001300226245010300239856005500342300001000397490000700407520120900414022002501623       2020                            d  bScientific Research Publishing, Inc.10aPolymorphism10aToll-Like Receptors1 aLima LNGC1 aMoura LS1 aLetícia Pinto Paz J1 aSilvestre MDPSA1 aSardinha D1 aMoura LDDO1 aLima KVB00aPolymorphisms of the Toll-Like Receptor-2 Gene in Patients with Leprosy and Their Healthy Contacts  uhttps://www.scirp.org/pdf/oji_2020081716020351.pdf  a37-460 v103 aLeprosy is an immunopathology caused by M. leprae; its evolution depends on immunological and genetic aspects of the host. The objective was verifying the relationship between SNPs 2029 and 2258 of the TLR-2 gene and leprosy. Blood samples from 127 individuals were analyzed: 45 patients, being 34 multibacillary (MB) and 11 paucibacillary (PB) and 82 contacts, in the municipalities of the State of Pará-Brazil. SNPs 2029 and 2258 of the TLR-2 gene were genotyped by sequencing on the ABI 3130 Genetic Analyzer (Applied Biosystems), analyzed using Fisher’s exact test. Distribution of SNP 2029 genotypes: all MB individuals presented the C/C genotype and the mutant (C/T) genotype was observed in contacts and PB. Alleles: all MB individuals presented only C allele and the mutant allele (T) was observed in contacts and PB. SNP 2258 genotypes: 79 contacts had G/G genotype and only 3 had G/A genotype, the MB group had only G/G genotype and the PB group was predominant G/G, with only 1 G/A genotype. Alleles: all MB individuals had allele G and the mutant allele (A) was observed in contacts and PB. The association between the SNPs and the susceptibility or protection to leprosy was not observed.  a2162-450X, 2162-4526