00852nas a2200181 4500000000100000008004100001260001200042100001000054700000900064700001100073700000900084700001100093245012000104300001600224490000700240520040900247022001400656 2020 d c08/20201 aLuo W1 aLu B1 aZhou R1 aHu X1 aWang J00aChemical Synthesis of the Trisaccharide Epitope of Phenolic Glycolipid-1 Surface Antigen from Mycobacterium leprae. a10973-109790 v853 a
PGL-1 epitope bearing a -aminoethylphenol group was efficiently synthesized by using linear synthetic routes. A method for efficient synthesis of oligosaccharides containing rhamnose rings was developed. The chemistry is flexible and could be used for the synthesis of other PGLs antigens. A biotinylated PGL-1 antigen was synthesized and could be used as a probe for early detection of leprosy.
a1520-6904