01743nas a2200265   4500000000100000008004100001260001300042653001600055653002400071653002900095653002300124653001100147653001200158653001300170653001900183653001800202653001300220653001400233100001400247245014400261300001100405490000700416520104000423022001401463       1990                            d  c1990 Feb10aClofazimine10aColitis, Ulcerative10aDermatitis Herpetiformis10aGlycosaminoglycans10aHumans10aleprosy10aPyoderma10aSulfanilamides10aSulfapyridine10aSulfones10aViscosity1 aStone O J00aSulfapyridine and sulfones decrease glycosaminoglycans viscosity in dermatitis herpetiformis, ulcerative colitis, and pyoderma gangrenosum.  a99-1030 v313 a<p>Shortly after the introduction of sulfa drugs, sulfapyridine was found to have unique therapeutic properties, unrelated to antibacterial activity. Later, sulfones were found to share the same properties. The disorders initially improved were dermatitis herpetiformis, pyoderma gangrenosum, subcorneal pustular dermatosis, acrodermatitis continua, impetigo herpetiformis and ulcerative colitis. They were also sometimes helpful in many other disorders. They are effective in select disorders characterized by edema followed by granulocytic inflammation or edema followed by vesicle or bullae formation. The sulfones work in low doses in leprosy and their mode of action is not fully understood. Several pieces of experimental information are available. It is proposed that these drugs are entering or influencing the protein moiety of glycosaminoglycans and decreasing tissue viscosity. This decreased tissue viscosity prevents edema and dilution of tissue fluid and decreases acute inflammation and vesicle and bullae formation.</p>  a0306-9877