02059nas a2200349   4500000000100000008004100001260001300042653001200055653002600067653002000093653002700113653003800140653002100178653002100199653002100220653001200241653002400253653000900277653002500286100001500311700000900326700001500335700001400350700001400364700001500378245012300393856004100516300001000557490000700567520112100574022001401695       1990                            d  c1990 Mar10aAnimals10aAntibodies, Bacterial10aCercopithecidae10aDisease Susceptibility10aEnzyme-Linked Immunosorbent Assay10aImmunity, Innate10aImmunoglobulin G10aImmunoglobulin M10aleprosy10aLipopolysaccharides10aMale10aMycobacterium leprae1 aGormus B J1 aXu K1 aMeyers W M1 aWalsh G P1 aLevis W R1 aMeeker H C00aAntibodies to lipoarabinomannan antigen in sooty mangabey monkeys experimentally inoculated with Mycobacterium leprae.  uhttp://ila.ilsl.br/pdfs/v58n1a10.pdf  a65-720 v583 a<p>IgG and IgM antibody levels to mycobacterial lipoarabinomannan (LAM) antigen were determined by ELISA in eight sooty mangabey monkeys (Cercocebus atys) prior to and at intervals after experimental inoculation with Mycobacterium leprae. High levels of anti-LAM IgG were present before inoculation and increased thereafter in the five mangabeys that developed lepromatous (LL) forms of leprosy; lower levels of anti-LAM IgG were observed in two mangabeys that developed indeterminate leprosy and tuberculoid/neuritic leprosy, respectively, and in a mangabey that was leprosy resistant. IgM anti-LAM levels were near zero before M. leprae inoculation in all eight animals, rose significantly in only three LL-leprosy-susceptible animals after inoculation, and returned to near zero in all animals within 3 years. Anti-LAM antibody levels appear to be potentially valuable as an indicator of leprosy susceptibility, and when measured longitudinally together with antibody levels to M. leprae-specific phenolic glycolipid-I antigen, as a means to detect preclinical M. leprae infections in high-risk individuals.</p>
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