01306nas a2200289   4500000000100000008004100001260001200042100001100054700001000065700000900075700001300084700001100097700001100108700001400119700001000133700001400143700001100157700001000168700001100178700001700189245007600206856008300282300001000365490000600375520062100381022001401002       2019                            d  c01/20191 aChoi H1 aCho S1 aHa Y1 aOcampo B1 aPark S1 aChen S1 aBennett C1 aHan J1 aRossner R1 aKang J1 aLee Y1 aPark S1 aKaeberlein M00aDDS promotes longevity through a microbiome-mediated starvation signal.  uhttps://www.sciencedirect.com/science/article/pii/S2468501119300045?via%3Dihub  a64-690 v33 a<p>The antibiotic diaminodiphenyl sulfone (DDS) is used in combination with other antibiotics as a first line treatment for leprosy. DDS has been previously reported to extend lifespan in  through inhibition of pyruvate kinase and decreased mitochondrial function. Here we report an alternative mechanism of action by which DDS promotes longevity in  by reducing folate production by the microbiome. This results in altered methionine cycle metabolite levels mimicking the effects of metformin and lifespan extension that is dependent on the starvation- and hypoxia-induced flavin containing monoxygenase, FMO-2.</p>  a2468-5011