01850nas a2200337   4500000000100000008004100001260001300042653001000055653002400065653002000089653001100109653001600120653001100136653001200147653001100159653000900170653001600179653001400195653002500209653002400234653001600258100001400274700001400288700001700302245014100319856004100460300001000501490000700511520098000518022001401498       1990                            d  c1990 Sep10aAdult10aAntigens, Bacterial10aCells, Cultured10aFemale10aGlycolipids10aHumans10aleprosy10aLipids10aMale10aMiddle Aged10aMonocytes10aMycobacterium leprae10aOxidation-Reduction10aSuperoxides1 aVachula M1 aWorobec S1 aAndersen B R00aA comparison of monocyte oxidative responses in leprosy patients and healthy subjects as influenced by mycobacterial lipid pretreatment.  uhttp://ila.ilsl.br/pdfs/v58n3a11.pdf  a534-90 v583 a<p>Superoxide anion (O2-) release by monocytes from leprosy patients in a paired study was lower than that released by monocytes from healthy controls. Pretreatment of healthy control monocytes with phenolic glycolipid-I (PGL-I) of Mycobacterium leprae resulted in the release of less O2- than released by buffer-treated cells or cells pretreated with structurally similar lipids. However, pretreatment of patient monocytes with PGL-I did not affect the O2- generation, perhaps because the cells already had a lower capacity to produce O2-. Upon further examination of the data from the patient population, monocytes from lepromatous patients released significantly less O2- than cells from normal controls, while tuberculoid patient cells released O2- in amounts similar to that generated by cells from normal controls. In addition, monocytes from patients with a high bacterial index had a lower capacity to generate O2- when compared to cells from healthy individuals.</p>  a0148-916X