01788nas a2200337   4500000000100000008004100001260001300042653002300055653001800078653001200096653001300108653001900121653001700140653002200157653002800179653003400207653000900241653001500250100001100265700001200276700001200288700001200300700001200312700001800324245010600342856004100448300001100489490000700500520092900507022001401436       1990                            d  c1990 Jun10aAnimals, poisonous10aB-Lymphocytes10aleprosy10aLymphoma10aMacaca mulatta10aNasal Mucosa10aPeripheral nerves10aRetroviridae Infections10aSimian immunodeficiency virus10aSkin10aSkin Tests1 aWalsh 1 aGormus 1 aBaskin 1 aMartin 1 aMeyers 1 aMurphey-Corb 00aPathology of dual Mycobacterium leprae and simian immunodeficiency virus infection in rhesus monkeys.  uhttp://ila.ilsl.br/pdfs/v58n2a12.pdf  a358-640 v583 a<p>Three rhesus monkeys were experimentally inoculated with sooty-mangabey-derived Mycobacterium leprae and were inadvertently infected with the simian immunodeficiency virus (SIV) as well. They died of an immunodeficiency syndrome, and at autopsy all had lesions caused by M. leprae. One monkey was inoculated twice with M. leprae, initially with an inoculum from a sooty mangabey that was not infected with SIV and, subsequently, with an inoculum from a mangabey that was SIV infected. The monkey did not develop clinical lesions and became strongly lepromin skin test (LST) positive after the first inoculation, but became infected with both agents and LST negative following the second inoculation. These observations suggest that SIV-infected rhesus monkeys have an increased susceptibility to M. leprae infection and, by analogy, imply that HIV-infected human beings may have an increased susceptibility as well.</p>
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