02157nas a2200325   4500000000100000008004100001260000900042653002600051653002400077653001800101653002600119653003800145653001600183653001100199653001200210653002500222653001400247653003000261653001400291100001500305700001500320700001400335700001500349700001100364245017200375300001100547490000700558520125200565022001401817       1990                            d  c199010aAntibodies, Bacterial10aAntigens, Bacterial10aCarrier State10aCost-Benefit Analysis10aEnzyme-Linked Immunosorbent Assay10aGlycolipids10aHumans10aleprosy10aMycobacterium leprae10aPolynesia10aPredictive Value of Tests10aPrognosis1 aChanteau S1 aCartel J L1 aSpiegel A1 aPlichart R1 aRoux J00a[The detection of IgM antibodies to phenolglycolipid I for serodiagnosis of Hansen's disease and monitoring the contact population in Polynesia. Five year evaluation].  a649-570 v833 a<p>This study was conducted to assess the usefulness of IgM anti-PGLI antibody test, for the diagnosis of leprosy and of the subclinical infection among contact population. Even if the specificity (97.7%), sensitivity (98% for the multibacillary, but 36% for the paucibacillary) and efficiency (97.7%) of the test for the diagnosis of patients are good, its positive predictive value which is the proportion of true patients among the seropositive subjects detected in the population was very low (1.17% in Polynesia), because of the very low prevalence of leprosy. For the diagnosis of the subclinical infection, our experience based on the follow up of a population of 1,123 contacts, showed that such a control program would have low feasibility and low cost-effectiveness. After 5 years, the proportion of individuals developing the disease was not different among the seropositive than among the seronegative subjects. Finally, only 17.5% of the new cases of leprosy detected, were issued from the contact population followed. In conclusion and in a practical point of view, although this test may contribute to the diagnosis of patients, it is not likely useful neither for the diagnosis nor for the prognosis of leprosy in a population.</p>  a0037-9085