00909nas a2200157   4500000000100000008004100001260001200042653003600054653001400090653002100104100001100125700001400136245007700150520051000227022001400737       2019                            d  c11/201910aAngiotensin II Receptor Blocker10aValsartan10aVenous Leg Ulcer1 aHirt P1 aLev-Tov H00aUse of topical Valsartan as a novel treatment of complicated leg ulcers.3 a<p>Venous leg ulcers (VLUs) are painful, recalcitrant to therapy and represent a significant burden on quality of patients' life and society (1). Therefore, innovative therapies are needed. Recently, the role of the renin-angiotensin system (RAS) in wound healing has been characterized in animal models (2). Given the availability and excellent safety profile of various RAS modulators, successful repurposing of these drugs to improve healing of chronic ulcers may prove useful in clinical settings.</p>  a1365-2133