01425nas a2200277   4500000000100000008004100001260001300042653002400055653002600079653001200105653003000117653001100147653001400158653002300172653001200195100001500207700001700222700001500239700001500254245006500269856004100334300001200375490000700387520073900394022001401133       1990                            d  c1990 Jun10aComputer Simulation10aCost-Benefit Analysis10aDapsone10aDrug Therapy, Combination10aHumans10aIncidence10aLeprostatic Agents10aleprosy1 aLechat M F1 aDeclercq E E1 aMisson C B1 aVellut C M00aSelection of MDT strategies through epidemiometric modeling.  uhttp://ila.ilsl.br/pdfs/v58n2a03.pdf  a296-3010 v583 a<p>The epidemiometric model of leprosy, built on Polambakkam, India, data, is used to compare the impact on incidence of dapsone and different multidrug therapy (MDT) strategies. The simulations show that generalization of MDT could have a dramatic impact on transmission of the disease. Relapses after MDT, although important from an individual point of view, have a negligible influence on the incidence. Introduction of MDT requires investments that, during the first few years of the program, are much greater than for dapsone monotherapy. These are, however, rapidly absorbed due to the rapidly declining number of new cases, particularly when MDT is not limited to multibacillary cases but is administered to all patients.</p>
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