02099nas a2200409   4500000000100000008004100001260000900042653002600051653002400077653001100101653001000112653003800122653002600160653001100186653001600197653001100213653002100224653001200245653000900257653002500266653001300291100002200304700001300326700001200339700001200351700001500363700001400378700001200392700001300404700001400417245014000431856005700571300000900628490001500637520102300652022001401675       2008                            d  c200810aAntibodies, Bacterial10aAntigens, Bacterial10aBrazil10aChild10aEnzyme-Linked Immunosorbent Assay10aEpidemiologic Methods10aFemale10aGlycolipids10aHumans10aImmunoglobulin M10aleprosy10aMale10aMycobacterium leprae10aStudents1 aBührer-Sékula S1 aBeers SM1 aOskam L1 aLecco R1 aMadeira ES1 aDutra MAL1 aLuis MC1 aFaber WR1 aKlatser P00aThe relation between seroprevalence of antibodies against phenolic glycolipid-I among school children and leprosy endemicity in Brazil.  uhttp://www.scielo.br/pdf/rsbmt/v41s2/en_v41s2a17.pdf  a81-80 v41 Suppl 23 a<p>Leprosy control programs would benefit expressively from an easy method to estimate disease prevalence and to assess the effect of leprosy control measures on disease prevalence. Determination of the seroprevalence of antibodies to PGL-I through school children surveys might be a useful indicator of leprosy prevalence at the district level. To investigate whether seropositivity rates could be related to leprosy detection rates and whether seropositivity could be used as a proximal indicator to predict the leprosy incidence in other areas, 7,073 school children in three different leprosy-endemic states in Brazil were tested. The results show a widely varying distribution of seropositivity in the communities independent of the number of leprosy cases detected. Seroprevalence was significantly lower at private schools. No differences in the patterns of seropositivity between ELISA and dipstick were observed. No correlation between leprosy detection rate and seropositivity rates could be established.</p>  a1678-9849