01297nas a2200301   4500000000100000008004100001260001300042653000900055653002200064653001600086653001900102653001100121653001100132653002500143653000900168653003500177653002700212653000900239100001200248700001200260700001700272700001700289245008300306300001100389490000700400520057400407022001400981       1990                            d  c1990 Aug10aAged10aAged, 80 and over10aClofazimine10aDrug Eruptions10aFemale10aHumans10aLeprosy, lepromatous10aMale10aNeuronal Ceroid-Lipofuscinoses10aPigmentation Disorders10aSkin1 aJob C K1 aYoder L1 aJacobson R R1 aHastings R C00aSkin pigmentation from clofazimine therapy in leprosy patients: a reappraisal.  a236-410 v233 a<p>Skin biopsy specimens from two lepromatous leprosy patients with dark brown pigmentation who were receiving long-term clofazimine therapy were studied. Ceroid-lipofuscin pigment was demonstrated inside macrophages that contained numerous phagolysosomes. These contained lipids and clofazimine that appeared as electron-lucent vacuoles and a lipofuscin pigment that was electron dense, granular, and lamellated. Although the presence of the drug in tissues contributed to the skin pigmentation, the main cause was a drug-induced, reversible ceroid lipofuscinosis.</p>  a0190-9622