01886nas a2200397   4500000000100000008004100001260001700042653001500059653001000074653001200084653001000096653001400106653001100120653002200131653001100153653001300164653001200177653002500189653000900214653002800223653002700251653001400278100001600292700001400308700001300322700001400335700001300349700001100362700001500373245007900388300001100467490000700478050003200485520095700517022001401474       1990                            d  c1990 Oct-Dec10aAdolescent10aAdult10aAtrophy10aChild10aEpidermis10aFemale10aFollow-Up Studies10aHumans10aLepromin10aleprosy10aLeprosy, Tuberculoid10aMale10aNervous System Diseases10aPigmentation Disorders10aSensation1 aAgarwal U S1 aHanda A K1 aMathur D1 aMehta R D1 aMittal A1 aDhar N1 aMathur N K00aHypopigmented lesions in early leprosy--a clinical and histological study.  a416-210 v62  aInfolep Library - available3 a<p>26 Patients of leprosy presenting with hypopigmented lesions were divided on morphological grounds into 3 Sub groups, Group I (9 patients) with well-defined single patch with moderate to complete sensory loss; Group II (8 patients) with single ill-defined lesion having partial sensory loss; and Group III (9 patients) having multiple hypo-pigmented patches with mild to moderate sensory loss. Epidermal atrophy was a conspicuous histological finding in all groups. Only patients in Group I showed epitheloid cells in dermal infiltrate with erosion of epidermis in one case. This group may be labelled as maculoanesthetic leprosy. Patients in Group II and III showed mononuclear cell infiltrate in dermis, around neurovascular bundles and appendages. They were histologically consistent with indeterminate leprosy. Follow-up biopsy after six to eight months of treatment showed healing of the lesion of reduction in the infiltrate in most cases.</p>  a0254-9395