01577nas a2200277   4500000000100000008004100001260001300042653001200055653003000067653001200097653003000109653002100139653001200160653000900172653001500181653002500196653001300221100001700234700002800251245014800279856004100427300001000468490000700478520080000485022001401285       1990                            d  c1990 Dec10aAnimals10aCombined Modality Therapy10aDapsone10aDrug Therapy, Combination10aInterferon-gamma10aleprosy10aMice10aMice, Nude10aRecombinant Proteins10aRifampin1 aBanerjee D K1 aMcDermott-Lancaster R D00aEffect of simultaneous administration of interferon-gamma and chemotherapy against Mycobacterium leprae in experimental infection in nude mice.  uhttp://ila.ilsl.br/pdfs/v58n4a07.pdf  a690-60 v583 a<p>The possibility of synergy between immunotherapy with recombinant interferon-gamma (IFN-gamma) and chemotherapy with rifampin (RMP) and dapsone (DDS) against Mycobacterium leprae was examined in nude mice. IFN-gamma alone failed to show any effect on the growth of M. leprae in the nude mouse foot pad. No synergy was demonstrable between DDS, either at 0.0001% or at 0.001%, and IFN-gamma. A subinhibitory level of RMP with IFN-gamma was also ineffective, but RMP at 0.006% with IFN-gamma produced a statistically significant enhancement of killing (26-fold) when compared with RMP at 0.006% only. It should be emphasized, however, that results obtained in the immunodeficient nude mouse model may not be comparable to those which might have been given by lepromatous leprosy patients.</p>
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