01073nas a2200277   4500000000100000008004100001260001300042653001200055653001400067653001100081653002300092653002600115653001200141653002600153653001600179653000900195653001500204653001800219100001300237700001300250245004000263300000900303490000600312520046300318022001400781       1991                            d  c1991 Feb10aAnimals10aCytokines10aHumans10aImmunity, Cellular10aKiller Cells, Natural10aleprosy10aLymphocyte Activation10aLymphokines10aMice10aPhagocytes10aT-Lymphocytes1 aKaplan G1 aCohn Z A00aLeprosy and cell-mediated immunity.  a91-60 v33 a<p>The intradermal injection of the purified protein derivative of tuberculin into lepromatous leprosy patients leads to a local cell-mediated immune response and to the extensive destruction of Mycobacterium leprae. This local response also occurs after intradermal injection of recombinant human interleukin-2; when administered over an 8-day period interleukin-2 evokes a systemic cell-mediated immune response and a reduction in the bacillary burden.</p>  a0952-7915