01317nas a2200373   4500000000100000008004100001260001300042653001200055653002300067653003100090653002000121653002000141653001100161653002100172653001200193653002600205653001600231653000900247653002900256653001400285653001700299100001300316700001100329700001500340700001500355700001300370700001100383700001400394245007000408300001000478490000700488520043400495022001400929       1991                            d  c1991 Mar10aAnimals10aChromosome Mapping10aGene Expression Regulation10aGenes, Dominant10aGenetic Markers10aHumans10aImmunity, Innate10aleprosy10aMacrophage Activation10aMacrophages10aMice10aMycobacterium Infections10aPhenotype10aTuberculosis1 aSchurr E1 aMalo D1 aRadzioch D1 aBuschman E1 aMorgan K1 aGros P1 aSkamene E00aGenetic control of innate resistance to mycobacterial infections.  aA42-50 v123 a<p>The Mendelian segregation of resistance to infection in different strains of mice infected with mycobacteria, Salmonella and Leishmania spp, all of which live in macrophages, is currently under close scrutiny. Here, Erwin Schurr and colleagues review the nature and function of the Bcg gene in controlling innate resistance to mycobacterial infection in mice and speculate on the occurrence of a possible human equivalent.</p>  a0167-5699