02083nas a2200409   4500000000100000008004100001260001300042653001000055653002500065653001000090653001100100653001900111653002300130653001100153653001200164653001100176653000900187653001600196653001500212653001700227100001900244700001700263700001200280700001300292700001500305700001700320700001400337700001600351700001500367700001200382245004800394856004100442300001000483490000700493520115900500022001401659       1991                            d  c1991 Jun10aAdult10aCase-Control Studies10aChild10aFemale10aHIV Infections10aHIV Seropositivity10aHumans10aleprosy10aMalawi10aMale10aMiddle Aged10aOdds Ratio10aRisk Factors1 aPonnighaus J M1 aMwanjasi L J1 aFine PE1 aShaw M A1 aTurner A C1 aOxborrow S M1 aLucas S B1 aJenkins P A1 aSterne J A1 aBliss L00aIs HIV infection a risk factor for leprosy?  uhttp://ila.ilsl.br/pdfs/v59n2a01.pdf  a221-80 v593 a<p>A case control study was undertaken during 1988 and 1989 within the framework of the LEPRA Evaluation Project (LEP)/Karonga Prevention Trail (KPT) in Karonga District, northern Malawi, to investigate whether HIV infection is a risk factor for clinical leprosy. Cases were newly ascertained, biopsy-confirmed, incident leprosy patients older than 14 years of age. Controls were selected from the computer data base on over 170,000 people who form the basis of LEP/KPT. They were matched for sex, age, and area of residence. HIV seropositivity rates were 1.8% (2/112) for incident leprosy cases and 2.4% (24/1011) for controls. The Mantel Haenszel odds ratio is 0.6 (95% confidence interval 0.1-3.3). Thus, no evidence for an association between HIV infection and leprosy incidence has been observed in this population. In a parallel investigation, an odds ratio of 7.4% (95% confidence interval 3.3-16.7) was found for 102 microscopy- and/or culture-confirmed, incident pulmonary tuberculosis cases in the same population during 1989, a result similar to those obtained elsewhere in Africa. Among leprosy relapses, 16.7% (2/12) were HIV positive.</p>
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