01945nas a2200337   4500000000100000008004100001260001700042653001200059653001200071653004100083653003000124653001100154653001000165653002300175653001200198653000900210653002400219653003200243653002500275653001300300100001400313700001300327700001500340245011100355856007800466300001000544490000700554050003200561520100000593022001401593       2009                            d  c2009 Jul-Sep10aAnimals10aDapsone10aDrug Resistance, Multiple, Bacterial10aDrug Therapy, Combination10aHumans10aIndia10aLeprostatic Agents10aleprosy10aMice10aMice, Inbred BALB C10aMicrobial Sensitivity Tests10aMycobacterium leprae10aRifampin1 aGupta U D1 aKatoch K1 aKatoch V M00aStudy of rifampicin resistance and comparison of dapsone resistance of M. leprae in pre- and post-MDT era.  uhttp://www.ijl.org.in/July-Sept%202009_PDF%20Files/4_Abst%20(131-134).pdf  a131-40 v81  aInfolep Library - available3 a<p>The aim of this study to study the drug resistance patterns of dapsone (pre- and post-MDT) and rifampicin (post-MDT era). All the 84 patients from pre-MDT period (1985-1990) and 77 patients for post-MDT period (1990-2002) reporting to a tertiary care hospital-NJIL & OMD, Agra and referred for drug susceptibility testing were included in the study. Drug resistance was studied by mouse foot pad method. Dapsone resistance was high during pre-MDT era i.e. 8.3% (medium) and 19.1% (high) with an overall dapsone resistance of 27.4%. During the post-MDT era, the dapsone resistance was low i.e. 1.3% (medium) and 3.9% (high) respectively (overall dapsone resistance-5.2%). While no comparison with pre-MDT era is available, the rifampicin resistance in these selected self-reporting cases during the post-MDT era was comparatively rather high (9.1%). MDT appears to have been useful in reducing the prevalence of dapsone resistance in leprosy patients reporting to a tertiary care hospital.</p>  a0254-9395