01201nas a2200217   4500000000100000008004100001260000900042653001400051653001100065653002100076653001200097653002500109653003500134100001500169700001400184245007400198300000900272490000800281520068000289022001400969       2010                            d  c201010aCytokines10aHumans10aImmunity, Innate10aleprosy10aMycobacterium leprae10aReceptors, Pattern Recognition1 aMontoya DJ1 aModlin RL00aLearning from leprosy: insight into the human innate immune response.  a1-240 v1053 a<p>Investigation into the innate immune response in leprosy has provided insight into host defense and immunopathology in human infectious disease. A key advance has been the delineation of pattern recognition receptors that detect pathogen-associated molecular patterns of the bacterium that causes leprosy, Mycobacterium leprae. From this knowledge, it has been possible to determine the cytokine responses as well as macrophage and dendritic cell differentiation programs that contribute to host defense and tissue injury in leprosy. These insights provide targets for therapeutic intervention to modulate innate immune responses against microbial infection in humans.</p>  a1557-8445