01445nas a2200301   4500000000100000008004100001260001300042653001200055653002000067653002700087653002700114653001400141653001400155653001200169653001900181653002000200653002000220100001500240700001500255700001400270700001500284700001600299245007000315300000900385490000700394520072800401022001401129       1991                            d  c1991 Apr10aAnimals10aCercopithecidae10aCercopithecus aethiops10aDisease Models, Animal10aHominidae10aHylobates10aleprosy10aMacaca mulatta10aMonkey Diseases10aPan troglodytes1 aMeyers W M1 aGormus B J1 aWalsh G P1 aBaskin G B1 aHubbard G B00aNaturally acquired and experimental leprosy in nonhuman primates.  a24-70 v443 a<p>Naturally-acquired leprosy has been observed in chimpanzees and sooty mangabey monkeys. Experimental multibacillary leprosy was established in 24 of 36 mangabey monkeys, 7 of 34 rhesus monkeys, and 15 of 19 African green monkeys following intravenous and intradermal inoculation of Mycobacterium leprae. The experimental disease strongly resembles leprosy in humans clinically, histopathologically, and immunologically. Thus, in addition to nine-banded armadillos in Louisiana and Texas, chimpanzees and sooty mangabeys in Africa, in the wild or in captivity, may serve as a zoonotic source of M. leprae. Investigators using chimpanzees and monkeys should be alerted to the possibility of naturally-acquired leprosy.</p>  a0002-9637