01716nas a2200301   4500000000100000008004100001260001300042653003700055653001900092653001900111653001900130653002000149653002000169653001100189653002100200653002800221653001100249100001200260700001000272700001000282700001000292700001000302245008900312300001000401490000700411520098200418022001401400       2010                            d  c2010 Jul10aAsian Continental Ancestry Group10aGene Frequency10aHLA-A Antigens10aHLA-B Antigens10aHLA-DR Antigens10aHLA-DRB1 Chains10aHumans10aImmunity, Innate10aLeprosy, Multibacillary10aTaiwan1 aHsieh N1 aChu C1 aLee N1 aLee H1 aLin M00aAssociation of HLA-DRB1*0405 with resistance to multibacillary leprosy in Taiwanese.  a712-60 v713 a<p>Host factors play an important role in determining the immune response and development of leprosy. The human leukocyte antigen system (HLA) has repeatedly been found to be associated with the pathogenesis of leprosy. This study analyzes the polymorphism of the HLA class I and II antigens in multibacillary leprosy patients and a healthy control group to provide predictable prognostic indicators and/or a differential diagnostic for the disease. Sixty-5 multibacillary leprosy patients from Lo-Sheng Leprosarium and 190 healthy Taiwanese were used as cases and controls, respectively. A serologic method was initially used for HLA-A and HLA-B antigen determination, and sequence-based typing was later applied for HLA-DRB1 allele typing. Although no significant associations were found with HLA-A or HLA-B antigens, this study shows a strong HLA-DRB1*0405 association with resistance to multibacillary leprosy, supporting results previously reported in the literatures.</p>  a1879-1166