01219nas a2200229   4500000000100000008004100001260001300042653001200055653003100067653001100098653002100109653001200130653003100142653003500173100001400208245004300222856014400265300001000409490000700419520054900426022001400975       2010                            d  c2010 Feb10aAnimals10aHost-Pathogen Interactions10aHumans10aImmunity, Innate10aleprosy10aMycobacterium lepraemurium10aReceptors, Pattern Recognition1 aModlin RL00aThe innate immune response in leprosy.  uhttps://www.frontiersin.org/articles/10.3389/fimmu.2018.00518/full?utm_source=F-NTF&utm_medium=EMLX&utm_campaign=PRD_FEOPS_20170000_ARTICLE  a48-540 v223 a<p>Investigation into the innate immune response in leprosy has provided insight into immunoregulation in human infectious disease. Key advances include the role of pattern recognition receptors in recognizing pathogen-associated molecular patterns of Mycobacterium leprae, cytokine release by innate immune cells, macrophage and dendritic cell differentiation, as well as antimicrobial effector pathways. These insights provide targets for therapeutic intervention in modulating the course of leprosy and other chronic infectious diseases.</p>  a1879-0372