01603nas a2200349   4500000000100000008004100001260001300042653002500055653001600080653001200096653003300108653003000141653001200171653001100183653001200194653002600206653001400232653000900246653001500255653001700270100001200287700001500299700001600314700001600330700001100346700001400357245012700371300001100498490000700509520072300516022001401239       1990                            d  c1990 Oct10aAlkaline Phosphatase10aAmino Acids10aAnimals10aBiological Transport, Active10aGamma-Glutamyltransferase10aGlucose10aKidney10aleprosy10aLeucyl Aminopeptidase10aMembranes10aMice10aMicrovilli10aTime Factors1 aKohli M1 aSharma V K1 aVaishnavi C1 aGanguly N K1 aKaur S1 aChugh K S00aRenal brushborder membrane vesicle. Study of marker enzymes and uptake of nutrients in Mycobacterium leprae infected mice.  a285-900 v603 a<p>The renal brush border membrane vesicles (BBMV) were used to elucidate the early biochemical functional status during the course of experimental M. leprae infection in mice. The activities of the characteristic brush-border enzymes viz: alkaline phosphatase, leucine amino peptidase and gamma-glutamyl transpeptidase were found to be significantly decreased (p less than 0.001) at 3 and 6 months after infection. The transport of nutrients viz: D-glucose, L-alanine, L-lysine and L-aspartate across BBMV showed similar pattern. The activity of brush border enzymes and transport of nutrients across the membrane returned to normal at 9 months post-infection suggesting regeneration of the brush border membrane.</p>  a0021-5031