01630nas a2200265   4500000000100000008004100001260001300042653002400055653003800079653001600117653001100133653001200144653002500156653003200181100001400213700001400227700001300241700002000254700001600274245007800290300001000368490000800378520096400386022001401350       1991                            d  c1991 Mar10aAntigens, Bacterial10aEnzyme-Linked Immunosorbent Assay10aGlycolipids10aHumans10aleprosy10aMycobacterium leprae10aSensitivity and Specificity1 aMahon A C1 aNurlign A1 aKebede B1 aBecx-Bleumink M1 aLefford M J00aUrinary phenolic glycolipid 1 in the diagnosis and management of leprosy.  a653-60 v1633 a<p>A simplified assay to measure the phenolic glycolipid 1 (PGL-1) of Mycobacterium leprae in the urine was applied to the diagnosis of leprosy and the monitoring of antileprosy chemotherapy. One hundred seventy-nine previously untreated patients and 25 normal controls were tested. The specificity of the assay was 100%. There were no false-positive results. The sensitivity of the assay varied with the type of leprosy from 92% for lepromatous leprosy to 56% for borderline lepromatous and 18% for borderline tuberculoid patients. After the onset of chemotherapy in lepromatous leprosy patients, there was often a transient increase of urinary PGL-1, followed by a steady decline. Within 3 months of multiple drug therapy, urinary PGL-1 levels were reduced by 90%-99% and were often undetectable. This assay appears to have considerable potential for monitoring chemotherapy and detecting treatment failure and relapse in patients with Hansen's disease.</p>  a0022-1899