02528nas a2200337   4500000000100000008004100001260000900042653001800051653000900069653002600078653002800104653002300132653001100155653001100166653001600177653002800193653003100221653000900252653003000261653002800291653002900319100001500348700001600363700001700379700001800396245010800414300001100522490000700533520163600540022001402176       2009                            d  c200910aActinomycosis10aAged10aAnti-Bacterial Agents10aDiagnosis, Differential10aErythema Induratum10aFemale10aHumans10aLymph Nodes10aMolecular Sequence Data10aMycobacterium tuberculosis10aNeck10apolymerase chain reaction10aTuberculosis, Cutaneous10aTuberculosis, Lymph Node1 aOwczarek W1 aTargowski T1 aŁebkowska K1 aPaluchowska E00a[Tubercular inflammation of cervical lymph nodes with a colliquative tuberculosis focus--a case study].  a417-210 v773 a<p>Cutaneous tuberculosis is a specific form of tuberculosis, with various clinical pictures and resulting from either endo- or exogenous way of infection, immunological mechanisms and unfavourable conditions for mycobacterium development. The atypical course and symptoms of the disease may cause difficulties in obtaining proper diagnosis and, in consequence, result in delayed onset of appropriate treatment. When diagnosing cutaneous tuberculosis, a broad spectrum of differential diagnoses should be applied, taking into account other diseases, such as, among others, leishmaniasis, actinomycosis, leprosy or deep mycoses. In this report, a case of lymph node tuberculosis and of colliquative tuberculosis of the skin, at first erroneously diagnosed as actinomycosis, complicated by multiform erythema. In the reported case, no tuberculous bacilli were identified in bacteriological evaluations of bioptates, collected from the skin changes. The final diagnosis of the disease was determined by the presence of specific granulation tissue in the last of performed histopathological studies, as well as by hypersensitivity to tuberculin and the presence of mycobacterial DNA in PCR evaluation. According to the authors, in case of clinically suspected cutaneous tuberculosis, repeated (several) histopathological studies of samples from observed changes seem to be fairly justified. The results of histopathological studies should be completed by one of the methods of oligomycobacterial material evaluation, e.g. by identification of mycobacterial genetic material by means of nucleic acid amplification in the PCR method.</p>  a0867-7077