01214nas a2200229   4500000000100000008004100001260001300042653002100055653001100076653001200087653004500099653003900144653001800183653000900201653001800210100001400228245004600242300001000288490000700298520066500305022001400970       1977                            d  c1977 Jul10aErythema Nodosum10aHumans10aleprosy10aMycobacterium Infections, Nontuberculous10aPeripheral Nervous System Diseases10aSchwann Cells10aSkin10aSkin Diseases1 aWEDDELL G00aDisorders of peripheral cutaneous nerves.  a130-50 v693 a<p>The histopathology of leprosy is described with particular reference to its effects on peripheral cutaneous nerves. Mycobacterium leprae invade the Schwann and perineurial cells of peripheral cutaneous nerves preferentially. The organisms are eventually destroyed with their host cells by a cell-mediated immune response. The effect is a dying-back phenomenon without the formation of neuromata. The sensory effects are gradually increasing anesthesia and localized nerve trunk pain but seldom any peripheral sensory reference or paresthesiae. Peripheral nerves are shown to be zones where there is some degree of immunologic privilege for Myco. leprae.</p>  a0022-202X