02714nas a2200373   4500000000100000008004100001260001700042653001500059653001000074653000900084653001000093653002100103653002100124653003000145653001100175653001100186653001100197653001200208653000900220653001600229653001700245100001200262700001300274700001500287700001200302700001400314245011200328856008800440300001100528490000700539050003200546520174800578022001402326       2008                            d  c2008 Jul-Sep10aAdolescent10aAdult10aAged10aChild10aChild, Preschool10aDisabled Persons10aDrug Therapy, Combination10aFemale10aHumans10aInfant10aleprosy10aMale10aMiddle Aged10aTime Factors1 aArora M1 aKatoch K1 aNatrajan M1 aKamal R1 aYadav V S00aChanging profile of disease in leprosy patients diagnosed in a tertiary care centre during years 1995-2000.  uhttp://www.ijl.org.in/archives/archives/pdf/Abst%203%20(Changing%20Profile)%20F.pdf  a257-650 v80  aInfolep Library - available3 a<p>A hospital based retrospective study was carried out to determine change in the profile of disease in leprosy patients taking 1995 as baseline and compared with the profile seen in year 2000. A total of 2149 and 1703 cases were studied respectively of year 1995 and 2000. Male to female ratio slightly increased from 2.95:1 in year 1995 to 3.4:1 in year 2000. Majority of patients were of borderline type in both years. Proportion of cases with MB leprosy was nearly same in females (60.8%) and males (63.1%) in year 1995 and in year 2000 (64.8% females and 67.6% males). Proportion of highly bacillary cases has decreased over the years in females (from 20.95% in 1995 to 11.7% in year 2000, p=0.03) as well as in males (from 25% in 1995 to 15.5% in year 2000, p=0.001). Incidence of total reactions increased from 27.6% to 35.4% over the years which is significant (p<0.01). Proportion of type 1 reactions were more in reproductive age group in females in both years (p<0.05) and of type 2 reactions were significantly (p > or = 0.05) more in males in both years. Incidence of disability (both grade 1 and grade 2) was significantly more in males than in females in both years (p > or = 0.04). Grade 1 disability has significantly increased over years in females from 10.11% to 14.8%(p<0.03) as well as in males from 13.27% to 21.3%(p<0.001). Onset of reactions was associated with pregnancy/lactation in 62% of cases and with menopause in 21% of cases in 2000, which suggests strong correlation with hormonal imbalance. To conclude while leprosy incidence has declined after MDT, recognition and management of reactions in women around changes in their hormonal levels should be properly monitored for early and effective management.</p>  a0254-9395