02260nas a2200313   4500000000100000008004100001260001300042653002800055653002000083653001100103653001200114653003200126653003900158653001700197653004200214653002200256100001500278700002000293700001600313700001400329700001700343245008300360856005100443300000900494490000700503050003200510520139000542022001401932       2009                            d  c2009 Mar10aDecompression, Surgical10aGlucocorticoids10aHumans10aleprosy10aNerve Compression Syndromes10aPeripheral Nervous System Diseases10aPrednisolone10aRandomized Controlled Trials as Topic10aTreatment Outcome1 aVan Veen N1 aSchreuders TA R1 aTheuvenet W1 aAgrawal A1 aRichardus JH00aDecompressive surgery for treating nerve damage in leprosy. A Cochrane review.  uhttps://leprosyreview.org/article/80/1/00-0312  a3-120 v80  aInfolep Library - available3 a<p><b>OBJECTIVE: </b>Decompressive surgery is used for treating nerve damage in leprosy. We assessed the effectiveness of decompressive surgery for patients with nerve damage due to leprosy.</p><p><b>METHODS: </b>A broad search strategy was performed to find eligible studies, selecting randomised controlled trials (RCTs) comparing decompressive surgery alone or plus corticosteroids with corticosteroids alone, placebo or no treatment. Two authors independently assessed quality and extracted data. Where it was not possible to perform a meta-analysis, the data for each trial was summarised.</p><p><b>RESULTS: </b>We included two randomised controlled trials involving 88 people. The trials examined the added benefit of surgery over prednisolone for treatment of nerve damage of less than 6 months duration. After 2 years follow-up there was no significant difference in nerve function improvement between people treated with surgery plus prednisolone or with prednisolone alone. Adverse effects of decompression surgery were not adequately described.</p><p><b>CONCLUSIONS: </b>Evidence from randomised controlled trials does not show a significant added benefit of surgery over steroid treatment alone. Well-designed randomised controlled trials are needed to establish the effectiveness of the combination of surgery and medical treatment compared to medical treatment alone.</p>  a0305-7518