01008nas a2200217 4500000000100000008004100001260001300042653001200055653001800067653001500085653002600100653001100126653001200137653001400149100001300163245020200176300001000378490000700388520038100395022001400776 2009 d c2009 Mar10aElastin10aElephantiasis10aErysipelas10aHistory, 19th Century10aHumans10aleprosy10aPsoriasis1 aRyan T J00aElephantiasis, elastin, and chronic wound healing: 19th century and contemporary viewpoints relevant to hypotheses concerning lymphedema, leprosy, erysipelas, and psoriasis--review and reflections. a19-250 v423 a

Both wound healing and lymphedema have fibrosis of the skin in common. They also share destruction of elastin by elastases from neutrophils as a significant feature. These are not new observations, and the writings of Unna and Kaposi are recalled. The contemporary observations on elastin by Gerli and his team are discussed in the light of these much earlier opinions.

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