01330nas a2200289   4500000000100000008004100001260001300042653001200055653002600067653002100093653003300114653001200147653000900159653002500168653003100193653001500224100001300239700001400252700001500266700001400281700001300295245013000308300001200438490000700450520056900457022001401026       2009                            d  c2009 Sep10aAnimals10aAntitubercular Agents10aDiarylquinolines10aDrug Administration Schedule10aleprosy10aMice10aMycobacterium leprae10aMycobacterium tuberculosis10aQuinolines1 aGelber R1 aAndries K1 aParedes RM1 aAndaya CE1 aBurgos J00aThe diarylquinoline R207910 is bactericidal against Mycobacterium leprae in mice at low dose and administered intermittently.  a3989-910 v533 a<p>The diarylquinoline R207910 is profoundly bactericidal in a murine model of tuberculosis. Previously, R207910 was also found to be bactericidal for Mycobacterium leprae-infected mice during lag phase. Herein we evaluate the bactericidal efficacy of R207910 (1 to 120 mg/kg of body weight) when administered five times weekly, once weekly, and once monthly during logarithmic multiplication of M. leprae organisms. All treatments were found to be bactericidal, suggesting that both low and intermittent dosing with R207910 holds promise for leprosy patients.</p>  a1098-6596