01314nas a2200265   4500000000100000008004100001260001700042653001200059653001600071653001600087653003300103653001100136653001200147653000900159653000900168653003000177100001300207700001000220700001200230245014700242300001000389490000600399520062900405022001401034       1991                            d  c1991 Jan-Feb10aAnimals10aBone Marrow10aClofazimine10aDrug Evaluation, Preclinical10aFemale10aleprosy10aMale10aMice10aSister Chromatid Exchange1 aDash B C1 aRoy B1 aDas R K00aEvaluation of genotoxicity of clofazimine, an antileprosy drug, in mice in vivo. III. Sister chromatid exchange analysis in bone marrow cells.  a69-700 v53 a<p>The potential genotoxicity of an antileprosy drug, clofazimine, was evaluated in mice in an in vivo model by sister chromatid exchange (SCE) analysis. Three different dose levels (4, 20 and 40 mg/kg) were tested, and the animals were treated once daily for 15 days. Sister chromatid differential staining was done by BrdU-tablet implantation and FPG technique. All the doses tested here elevated the SCE frequencies significantly and the increases showed a significant positive correlation with the doses. The results confirm our earlier findings based on metaphase analysis and micronucleus test in the same species.</p>  a0258-851X