01413nas a2200301   4500000000100000008004100001260001300042653001000055653002000065653002200085653004300107653001200150653003500162653001100197653002300208653001200231653000900243100001600252700001300268700001700281245014700298856005100445300001100496490000700507050003200514520055100546022001401097       2008                            d  c2008 Dec10aAdult10aAgranulocytosis10aAnemia, Hemolytic10aChemical and Drug Induced Liver Injury10aDapsone10aGlucosephosphate Dehydrogenase10aHumans10aLeprostatic Agents10aleprosy10aMale1 aRanawaka RR1 aMendis S1 aWeerakoon HS00aDapsone-induced haemolytic anaemia, hepatitis and agranulocytosis in a leprosy patient with normal glucose-6-phosphate-dehydrogenase activity.  uhttps://leprosyreview.org/article/79/4/43-6440  a436-400 v79  aInfolep Library - available3 a<p>A 21 year old boy with borderline lepromatous leprosy and normal glucose-6-phosphate-dehydrogenase activity developed haemolytic anaemia, hepatitis and agranulocytosis following 19 weeks of multi-bacillary multi-drug therapy. With early administration of antibiotics and G-CSF our patient recovered without residual complications. All patients taking dapsone should be warned to discontinue the drug immediately in the event of fever, chills and sore throat occurring within the treatment period until further investigations are performed.</p>  a0305-7518