01302nas a2200277   4500000000100000008004100001260001300042653002400055653002700079653002400106653002000130653001700150653001100167653001200178653002500190653002500215653002500240653001800265100001400283245007200297300000900369490000700378050001700385520060800402022001401010       1991                            d  c1991 Apr10aAntigens, Bacterial10aDisease Susceptibility10aGenes, MHC Class II10aGenetic Markers10aHLA Antigens10aHumans10aleprosy10aLeprosy, lepromatous10aLeprosy, Tuberculoid10aMycobacterium leprae10aT-Lymphocytes1 aVries R R00aGenetic control of immunopathology induced by Mycobacterium leprae.  a12-60 v44  aDEVRIES 19913 a<p>The pathogenesis of leprosy is almost totally attributable to the immune response of the host towards Mycobacterium leprae, a virtually non-toxic intra-cellular parasite. At one end of the leprosy spectrum are tuberculoid leprosy patients, who develop immunity but also delayed-type hypersensitivity towards M. leprae; at the other end are lepromatous leprosy patients, who lack helper T cell activity and therefore do not develop immunity, but who can nevertheless produce antibodies that may cause immunopathology due to immune complexes. A range of immunopathology is seen between these poles.</p>  a0002-9637