01984nas a2200361   4500000000100000008004100001260001300042653001000055653002900065653001100094653001100105653001200116653000900128653001600137653002200153653002100175653001500196653001800211653002200229653001600251653002300267653001600290100001500306700002600321700001000347700001500357700001200372245011000384300001000494490000700504520109700511022001401608       2008                            d  c2008 Dec10aAdult10aAnti-Inflammatory Agents10aFemale10aHumans10aleprosy10aMale10aMiddle Aged10aNeural Conduction10aPain Measurement10aPrednisone10aReaction Time10aTreatment Outcome10aUlnar nerve10aUlnar Neuropathies10aYoung Adult1 aGarbino JA1 aCunha Lopes Virmond M1 aUra S1 aSalgado MH1 aNaafs B00aA randomized clinical trial of oral steroids for ulnar neuropathy in type 1 and type 2 leprosy reactions.  a861-70 v663 a<p><b>BACKGROUND: </b>Steroids regimens in leprosy neuropathies are still controversial in botth types of reactions.</p><p><b>METHOD: </b>For this trial, 21 patients with ulnar neuropathy were selected from 163 leprosy patients, 12 with type 1 reaction (T1R) and nine with type 2 (T2R). One experimental group started with prednisone 2 mg/kg/day and the control group with 1 mg/kg/day. A clinical score based on tests for spontaneous pain, nerve palpation, sensory and muscle function was used. Neurophysiological evaluation consisted on the motor nerve conduction of the ulnar nerve in three segments. Student "t" test for statistical analysis was applied on the results: before treatment, first week, first month and sixth month, between each regimen and types of reaction.</p><p><b>CONCLUSION: </b>In both reactions during the first month higher doses of steroids produced better results but, earlier treatment with lower dose was as effective. Short periods of steroid, 1 mg/Kg/day at the beginning and,tapering to 0,5 mg/Kg/day or less in one month turned out to be efficient in T2R.</p>  a1678-4227