01201nas a2200313   4500000000100000008004100001260001300042653001200055653003700067653003300104653002300137653001200160653000900172653000900181653002100190653002400211653002500235653001900260653002200279100001800301700001800319700001600337700001600353245011500369300001000484490000800494520037100502022001400873       2008                            d  c2008 Apr10aAnimals10aDose-Response Relationship, Drug10aDrug Evaluation, Preclinical10aLeprostatic Agents10aleprosy10aMale10aMice10aMice, Inbred CBA10aMicrobial Viability10aMycobacterium leprae10aThiocarbamates10aTreatment Outcome1 aUrlyapova N G1 aYuschenko A A1 aDaudova A D1 aMakarov V A00aAntileprosy activity and preliminary toxicological characteristics of some dialkyldithiocarbamate derivatives.  a446-80 v1453 a<p>Antileprosy activity of dialkyldithiocarbamate derivatives was studied in experiments on mice infected with M. leprae into paw pads. We found that 2-diethyldithiocarbamoyl-3-cyano-5-nitropyridine is the most promising antileprosy agent; it effectively suppresses multiplication of M. leprae and is well tolerated under conditions of chronic animal experiment.</p>  a0007-4888