01866nas a2200385   4500000000100000008004100001260001300042653001500055653001000070653001100080653001000091653001100101653001100112653001300123653001200136653000900148653001600157653002500173653001300198653002200211653000900233100001100242700001600253700001400269700001700283700001600300700001500316700001600331245008400347856004100431300001100472490000700483520097600490022001401466       1991                            d  c1991 Sep10aAdolescent10aAdult10aBiopsy10aChild10aFemale10aHumans10aLepromin10aleprosy10aMale10aMiddle Aged10aMycobacterium leprae10aNeuritis10aPeripheral nerves10aSkin1 aKaur G1 aGirdhar B K1 aGirdhar A1 aMalaviya G N1 aMukherjee A1 aSengupta U1 aDesikan K V00aA clinical, immunological, and histological study of neuritic leprosy patients.  uhttp://ila.ilsl.br/pdfs/v59n3a01.pdf  a385-910 v593 a<p>An assessment has been made of 108 neuritic leprosy patients to find out if the number of affected nerves and the clinical presentations of these patients give any indication of the underlying severity (classification) of the disease. Detailed clinical recordings, skin smears, lepromin testing with Dharmendra antigen, and a leukocyte migration inhibition test (LMIT) using sonicated Mycobacterium leprae antigens were done in these patients. Nerve biopsies of available affected nerves were taken in 39 patients. The results show that neuritic leprosy patients also have a spectrum. However, none of the clinical parameters, including the number and distribution of affected nerves, the immune response and the nerve histology, were found to be inter-related. Further, even though all of the patients were skin-smear negative, a significant proportion showed lepromatous histology and nearly two thirds had a moderate-to-heavy bacterial load within the nerves.</p>
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