01228nas a2200229   4500000000100000008004100001260000900042653001200051653001100063653001700074653001200091653001600103653003100119653002500150653001700175100001700192245007300209300001000282490000700292520068500299022001400984       1991                            d  c199110aAnimals10aHumans10aInterleukins10aleprosy10aMacrophages10aReceptors, Antigen, T-Cell10aT-Lymphocyte Subsets10aTuberculosis1 aKaufmann S H00aThe macrophage in tuberculosis: sinner or saint? The T cell decides.  a153-50 v593 a<p>Immunity to intracellular bacteria including Mycobacterium tuberculosis crucially depends on intricate interactions between T lymphocytes and macrophages. Before contact with T lymphocytes macrophages serve as habitat for M. tuberculosis organisms; after activation by T cells they become major effectors against these pathogens. T cells comprise different subsets which express different functional activities. This paper describes evidence that different T cell subsets (CD4 alpha/beta T cells, CD8 alpha/beta T cells and gamma/delta T cells) as well as different T cell functions (interleukin secretion and target cell lysis) contribute to immunity against tuberculosis.</p>  a1015-2008