01543nas a2200349   4500000000100000008004100001260001700042653001500059653001000074653000900084653002600093653003800119653001100157653001100168653002100179653002100200653002500221653000900246653001600255653002500271100001400296700001600310700001600326700001800342700001500360700001400375245005500389300001200444490000700456520071600463022001401179       1991                            d  c1991 Mar-Apr10aAdolescent10aAdult10aAged10aAntibodies, Bacterial10aEnzyme-Linked Immunosorbent Assay10aFemale10aHumans10aImmunoglobulin G10aImmunoglobulin M10aLeprosy, Tuberculoid10aMale10aMiddle Aged10aMycobacterium leprae1 aRoche P W1 aBritton W J1 aFailbus S S1 aTheuvenet W J1 aLavender M1 aAdiga R B00aSerological responses in primary neuritic leprosy.  a299-3020 v853 a<p>The serological responses to 2 Mycobacterium leprae specific epitopes and one common mycobacterial antigen were examined in 46 untreated patients with primary neuritic (PN) leprosy. M. leprae specific antibodies to the terminal disaccharide of phenolic glycolipid and/or the ML-04 defined epitope on the 35 kDa protein were detected in 41% of PN patients and 47% responded to one of the 3 antigens. This serological response mirrored that observed in paucibacillary leprosy patients. There was a significant increase in the level of antibody response when more nerve trunks were involved. Changes in antibody levels in seropositive PN patients may prove useful in monitoring the response to chemotherapy.</p>  a0035-9203