02114nas a2200337   4500000000100000008004100001260001300042653001000055653001100065653001600076653001200092653002800104653001100132653002300143653002500166653000900191653002200200653001600222653001300238653001100251653001100262100001800273700001400291700001100305700001300316245005100329300001000380490000600390520136600396022001401762       2008                            d  c2008 Sep10aAdult10aBiopsy10aClofazimine10aDapsone10aDiagnosis, Differential10aHumans10aLeprostatic Agents10aLeprosy, Tuberculoid10aMale10aNeural Conduction10aPhilippines10aRifampin10aSicily10aTravel1 aBongiorno M R1 aPistone G1 aNoto S1 aAricò M00aTuberculoid leprosy and Type 1 lepra reaction.  a311-40 v63 a<p>A patient is described with tuberculoid leprosy and Type 1 (lepra) reaction from Sicily a non-endemic region, who lived previously in Manila from 2000 to 2005. The skin lesions became acutely inflamed and edematous. The plaques were painless to touch or pinprick, and there was swelling of the nerves in the fibro-osseous tunnels under the surface of the skin, including both the ulnar nerve at the elbow, and the posterior tibial nerve (medial malleolus). During the course of electro-neurographic studies, conduction velocity in the motory nerves indicated a slowing-down. The diagnosis of leprosy was confirmed by residence in an endemic area for about 5 years, by simultaneous skin lesions and peripheral nerve abnormalities, and by skin biopsy. Outside of endemic areas, diagnosis remains a challenge for physicians for mainly two reasons. Firstly, the incubation period of leprosy is uniquely long among bacterial diseases and varies from a month to over 40 years. Secondly, outside leprosy-endemic areas, the diagnosis of leprosy is usually not considered, and patients are likely to be examined by a wide range of specialists. Physicians outside endemic areas should consider leprosy as a possible differential diagnosis if a patient from leprosy-endemic regions presents with painless skin lesions, nerve enlargement, or persistent skin lesions.</p>  a1477-8939