02842nas a2200445   4500000000100000008004100001260000900042653001500051653002800066653001000094653000900104653002200113653001000135653002100145653001100166653001100177653002300188653001200211653000900223653001600232653003900248653003200287653003100319653001700350653002200367653001600389100001600405700001700421700001800438700001200456700001300468700001200481245009900493856007700592300000900669490000600678050001800684520168000702022001402382       2008                            d  c200810aAdolescent10aAdrenal Cortex Hormones10aAdult10aAged10aAged, 80 and over10aChild10aChild, Preschool10aFemale10aHumans10aLeprostatic Agents10aleprosy10aMale10aMiddle Aged10aPeripheral Nervous System Diseases10aProportional Hazards Models10aReproducibility of Results10aRisk Factors10aTreatment Outcome10aYoung Adult1 aSchuring RP1 aRichardus JH1 aSteyerberg EW1 aPahan D1 aFaber WR1 aOskam L00aPreventing nerve function impairment in leprosy: validation and updating of a prediction rule.  uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2565693/pdf/pntd.0000283.pdf  ae2830 v2  aSCHURING 20083 a<p><b>BACKGROUND: </b>To validate and update a prediction rule for estimating the risk of leprosy-related nerve function impairment (NFI).</p><p><b>METHODOLOGY/PRINCIPAL FINDINGS: </b>Prospective cohort using routinely collected data, in which we determined the discriminative ability of a previously published rule and an updated rule with a concordance statistic (c). Additional risk factors were analyzed with a Cox proportional hazards regression model. The population consisted of 1,037 leprosy patients newly diagnosed between 2002 and 2003 in the health care facilities of the Rural Health Program in Nilphamari and Rangpur districts in northwest Bangladesh. The primary outcome was the time until the start of treatment. An NFI event was defined as the decision to treat NFI with corticosteroids after diagnosis. NFI occurred in 115 patients (13%; 95% confidence interval 11%-16%). The original prediction rule had adequate discriminative ability (c = 0.79), but could be improved by substituting one predicting variable: 'long-standing nerve function impairment at diagnosis' by 'anti-PGL-I antibodies'. The adjusted prediction rule was slightly better (c = 0.81) and identified more patients with NFI (80%) than the original prediction rule (72%).</p><p><b>CONCLUSIONS/SIGNIFICANCE: </b>NFI can well be predicted by using the risk variables 'leprosy classification' and 'anti-PGL-I antibodies'. The use of these two variables that do not include NFI offer the possibility of predicting NFI, even before it occurs for the first time. Surveillance beyond the treatment period can be targeted to those most likely to benefit from preventing permanent disabilities.</p>  a1935-2735