01438nas a2200313   4500000000100000008004100001260001300042653001200055653001500067653001700082653001200099653002300111653001200134653000900146653002400155653003200179653002500211653001300236100001500249700001500264700001300279700002100292700001600313245010900329300001000438490000700448520065500455022001401110       1991                            d  c1991 Mar10aAnimals10aArmadillos10aBenzylamines10aDapsone10aLeprostatic Agents10aleprosy10aMice10aMice, Inbred BALB C10aMicrobial Sensitivity Tests10aMycobacterium leprae10aRifampin1 aDhople A M1 aStrong L C1 aMeindl W1 aSchoenenberger H1 aGardner G D00aIn vitro and in vivo effects of N-methyl-3,5-dichloro-benzylamine hydrochloride on Mycobacterium leprae.  a253-60 v413 a<p>The antimicrobial effects of a new benzylamine, ME-93 (N-methyl-3,5-dichloro-benzylamine hydrochloride), alone and in combination with dapsone and rifampicin, have been evaluated in vitro in cell-free culture system and in vivo in mouse foot pad system. Even at 50 micrograms/ml, ME-93 did not completely inhibit the in vitro growth of M. leprae, and the effects were bacteriostatic. However, there was a synergism when ME-93 was combined with rifampicin, and the effects were bactericidal. Similar findings were also obtained in the mouse foot pad system. Thus, there is a new drug that needs further attention in the chemotherapy of leprosy.</p>  a0004-4172