02003nas a2200325   4500000000100000008004100001260001300042653001500055653001000070653002900080653001100109653001100120653002400131653002500155653000900180653001600189653000900205653001700214100001300231700001300244700001400257700001600271245006500287856005900352300001100411490000700422050003200429520120200461022001401663       1991                            d  c1991 Jun10aAdolescent10aAdult10aAnti-Inflammatory Agents10aFemale10aHumans10aLeprosy, Borderline10aLeprosy, Tuberculoid10aMale10aMiddle Aged10aSkin10aTime Factors1 aSaxena U1 aRamesh V1 aMisra R S1 aMukherjee A00aPersistent reaction in paucibacillary leprosy: case reports.  uhttp://leprev.ilsl.br/pdfs/1991/v62n2/pdf/v62n2a13.pdf  a206-110 v62  aInfolep Library - available3 a<p>Three patients of histopathologically confirmed borderline-tuberculoid leprosy showing no acid-fast bacilli and with lesions confined to the face, 2 on the cheek and 1 on the forehead, were given multidrug therapy as recommended by the WHO for paucibacillary cases. Within 3 months the lesions showed signs of upgrading (or reversal) reaction which was substantiated by histopathology. In 1 patient the facial nerve was affected leading to facial palsy. The lymphocyte transformation test did not show a significant rise. All 3 patients were given oral prednisolone for periods varying between 5 and 7 months, but the response was poor except in 1 patient in whom the facial palsy responded favourably. Injections of sodium antimony gluconate tried in 1 patient after stoppage of steroids did not control the reaction. After 18 months of regular follow-up during therapy, the cutaneous reaction in the patient with facial nerve involvement subsided leaving significant atrophy. However, in the other 2 patients the skin lesion persisted with clinical and histopathological evidence of upgrading reaction. The reasons for the unnatural persistence of reaction in these patients is not clear.</p>  a0305-7518