01803nas a2200361   4500000000100000008004100001260001300042653001500055653001000070653000900080653002400089653004400113653001100157653002400168653001100192653002300203653001200226653002600238653000900264653001600273653002500289653001000314653001800324100001400342700001800356700001600374245010800390856004100498300001000539490000700549520087100556022001401427       1992                            d  c1992 Mar10aAdolescent10aAdult10aAged10aAntigens, Bacterial10aDose-Response Relationship, Immunologic10aFemale10aHeat-Shock Proteins10aHumans10aImmunity, Cellular10aleprosy10aLymphocyte Activation10aMale10aMiddle Aged10aMycobacterium leprae10aNepal10aT-Lymphocytes1 aRoche P W1 aTheuvenet W J1 aBritton W J00aCellular immune responses to mycobacterial heat shock proteins in Nepali leprosy patients and controls.  uhttp://ila.ilsl.br/pdfs/v60n1a06.pdf  a36-430 v603 a<p>Sixty-three leprosy patients, representing the entire leprosy spectrum from tuberculoid to lepromatous disease, and 17 healthy Nepali subjects were tested for their T-cell responses to the purified p65 and p70 protein antigens of Mycobacterium bovis BCG using a lymphocyte proliferative assay. There was strong correlation between the responses to BCG and M. leprae and the responses to the two antigens. Patients and controls lacking a response to either of the whole cell preparations failed to respond to the purified antigens, while BCG responders at the lepromatous pole of the disease did mount a response to both antigens. Significant differences in the magnitude of the responses to these antigens were obtained between controls and the disease groups. In individual subjects, responses to the two antigens were significantly correlated to each other.</p>  a0148-916X