01573nas a2200361   4500000000100000008004100001260001700042653001200059653001800071653002700089653002700116653001200143653000900155653001500164653002500179653003700204653001800241100001100259700001500270700001200285700001400297700001800311700001500329700001200344700001200356700001200368700001300380245017300393300001100566490000700577520061300584022001401197       1991                            d  c1991 Jul-Dec10aAnimals10aB-Lymphocytes10aDisease Models, Animal10aDisease Susceptibility10aleprosy10aMice10aMice, SCID10aMycobacterium leprae10aSevere Combined Immunodeficiency10aT-Lymphocytes1 aYogi Y1 aNAKAMURA K1 aInoue T1 aKawatsu K1 aKashiwabara Y1 aSakamoto Y1 aIzumi S1 aSaito M1 aHioki K1 aNomura T00aSusceptibility of severe combined immunodeficient (SCID) mice to Mycobacterium leprae: multiplication of the bacillus and dissemination of the infection at early stage.  a139-450 v603 a<p>Inoculation of M. leprae were made into the both hind feet at a dose of 4.8 x 10(6) bacilli per foot in order to determine the susceptibility to M. leprae of SCID mice which is severely deficient in both T- and B cell immunity. SCID mice was found to have an extremely high susceptibility to M. leprae, and the progress of infection observed in the SCID mice were shown a rapid systemic spread of infection at the all over the tissues as well as the growth of the leprosy bacilli at the site of inoculation. Therefore, SCID mice can be used as a suitable multibacillary model for the study of leprosy.</p>  a0386-3980