02783nas a2200445   4500000000100000008004100001260001300042653001500055653001000070653002700080653002600107653001000133653001900143653003000162653003800192653002200230653001100252653002100263653002300284653001200307653001600319653001200335653002500347653001400372653001300386653000900399653003000408653001700438100001000455700001100465700001100476700001100487700001200498700001100510245010900521300000900630490000700639520167700646022001402323       2008                            d  c2008 Feb10aAdolescent10aAdult10aAntibiotic Prophylaxis10aAntibodies, Bacterial10aChild10aCohort Studies10aDrug Therapy, Combination10aEnzyme-Linked Immunosorbent Assay10aFollow-Up Studies10aHumans10aImmunoglobulin M10aLeprostatic Agents10aleprosy10aMinocycline10aMyanmar10aMycobacterium leprae10aOfloxacin10aRifampin10aRisk10aSeroepidemiologic Studies10aTime Factors1 aOo KN1 aYin NN1 aHan TT1 aWai KT1 aMyint K1 aGyi MM00aSerological response to chemoprophylaxis in extended contacts in leprosy--a randomized controlled trial.  a3-100 v773 a<p>Chemoprophylaxis was carried out on high risk group of extended contacts of new leprosy cases in Nyaungdon Township, Ayeyarwaddy Division, Myanmar and serological response was followed up for two years. In September 2003, blood samples were collected from 829 contacts after getting informed consent and sera were tested for immunoglobulin M antibodies using NTP-BSA ELISA test. These 300 seropositives were randomized to treated and non-treated groups. In each group 102 each were enrolled in adults and 48 each in children. A single dose of ROM (rifampicin, ofloxacin and minocycline) and RMP (rifampicin) by body weight was administered to treated group of above 15 years and those below 15 years respectively. The vitamins were administered to non-treated group. The blood samples of all contacts were collected again in September 2004 and September 2005 and ELISA was carried out on paired samples on one plate. The mean optical density (OD) titers before vs after chemoprophylaxis were 0.24 vs 0.10 and 0.20 vs 0.09 in treated and non-treated group respectively in adults and 0.25 vs 0.11 and 0.22 vs 0.11 respectively in children after one year. These were 0.24 vs 0.17 and 0.20 vs 0.19 respectively in adults and 0.25 vs 0.19 and 0.22 vs 0.20 respectively in children after two years. The difference of mean antibody titers before and after chemoprophylaxis in treated group was significantly reduced compared to non-treated group in adults but was not significant in children. The findings show that there is a significant role of chemoprophylaxis on serological response in the form of decreasing antibody titer among the adult group of extended contacts.</p>  a1342-3681