02336nas a2200289   4500000000100000008004100001260001300042653002800055653002500083653002100108653001100129653002500140653001700165100001500182700001200197700001600209700001400225700001500239700001500254245014400269856005100413300001100464490000700475050003200482520151800514022001402032       2007                            d  c2007 Dec10aAdrenal Cortex Hormones10aCase-Control Studies10aErythema Nodosum10aHumans10aLeprosy, lepromatous10aNitric Oxide1 aMohanty KK1 aGupta M1 aGirdhar B K1 aGirdhar A1 aChakma J K1 aSengupta U00aIncreased level of urinary nitric oxide metabolites in leprosy patients during type 2 reactions and decreased after antireactional therapy.  uhttps://leprosyreview.org/article/78/4/38-6390  a386-900 v78  aInfolep Library - available3 a<p><b>OBJECTIVES: </b>To assess the urinary nitric oxide metabolites in lepromatous patients in ENL (type 2 reactions) and to compare these metabolites after subsidence of reactions following antireactional therapy. Further to compare the levels in a group of lepromatous leprosy patients without reactions.</p><p><b>DESIGN: </b>The initial urine samples were collected from lepromatous leprosy patients when they came with ENL before commencing antireactional therapy and repeat samples were taken after resolution of ENL. Morning urine samples were collected from LL patients without reactions. Nitrites and nitrates in urine were measured using commercially available kit. Mean levels of nitric oxide metabolites of LL patients with ENL and without ENL were compared by student's 't' test. The level during ENL and after resolution was compared by paired 't' test.</p><p><b>RESULTS: </b>The nitric oxide metabolites were analyzed in 14 LL patients with ENL and after resolution of ENL and in 5 LL patients without reaction. The level of urinary nitric oxide metabolite is higher in LL patients in ENL reaction compared to LL patients without reaction (P < 0.04). These levels were reduced significantly with resolution of reaction following antireactional therapy (P < 0.004).</p><p><b>CONCLUSION: </b>The findings of this study suggested that the NO/NOM excretion is increased in leprosy patients during ENL episodes. With antireactional therapy (steroids) and clinical improvement the levels are reduced.</p>  a0305-7518