03404nas a2200349   4500000000100000008004100001260001300042653001000055653002500065653001300090653001700103653001100120653001100131653002200142653001200164653002400176653002500200653002300225653000900248653001600257653002500273100001600298700002000314700002000334245011900354856005100473300001000524490000700534050003200541520246700573022001403040       2007                            d  c2007 Dec10aAdult10aCase-Control Studies10aCatalase10aErythrocytes10aFemale10aHumans10aHydrogen Peroxide10aleprosy10aLeprosy, Borderline10aLeprosy, lepromatous10aLipid Peroxidation10aMale10aMiddle Aged10aSuperoxide Dismutase1 aPrasad BC V1 aKodliwadmath MV1 aKodliwadmath GB00aErythrocyte superoxide dismutase, catalase activities and hydrogen peroxide induced lipid peroxidation in leprosy.  uhttps://leprosyreview.org/article/78/4/39-1397  a391-70 v78  aInfolep Library - available3 a<p><b>OBJECTIVES: </b>To assess erythrocyte superoxide dismutase (SOD) and catalase (CAT) activities and hydrogen peroxide induced lipid peroxidation in leprosy.</p><p><b>DESIGN: </b>One hundred leprosy patients and 50 normal healthy controls were studied for the parameters. The data was analysed by grouping the patients into Ridley-Jopling (RJ) types [Tuberculoid leprosy (TT, n = 22), Borderline tuberculoid leprosy (BT, n = 28), Borderline leprosy (BB, n = 13), Borderline lepromatous leprosy (BL, n = 16) and Lepromatous leprosy (LL, n = 21)] and into different levels of Bacteriological Index (BI) [bacteriologically negative (n = 32), BI = 0.1-1 (n = 22), BI = 1.1-2 (n = 16), BI = 2.1-3 (n = 14), BI = 3.1-4 (n = 10) and BI = 4.1-6 (n = 06)].</p><p><b>RESULTS: </b>The induced peroxidation was significantly high and the enzyme activities were significantly low in leprosy (total patients) as compared to controls. A progressive increase in peroxidation was detected along the leprosy spectrum from TT to LL and the increase was significant in BB, BL and LL groups as compared to controls. Induced peroxidation in LL group as compared to TT, BT and BB and in the BL group as compared to TT and BT were significantly different. A concomitant progressive decline in enzyme activity was detected along the leprosy spectrum from TT to LL. The SOD activity in BB, BL and LL and the CAT activity in BL and LL were significantly low as compared to controls. SOD activity in BB, BL and LL groups as compared to TT and in the LL group as compared to BT were significantly different. A progressive trend of increasing peroxidation and decreasing SOD and CAT activity were also detected along the leprosy groups with advancing level of BI. Induced peroxidation and SOD activity were significantly different in bacteriologically positive groups as compared to controls and in the BI levels 1.1-2, 2.1-3, 3.1-4 and 4.1-6 as compared to bacteriologically negative group. The peroxidation was significantly different in BI levels 2.1-3, 3.1-4 and 4.1-6 as compared to BI level 0.1-1. The CAT activity was significantly different in BI levels 2.1-3, 3.1-4 and 4.1-6 as compared to controls.</p><p><b>CONCLUSION: </b>The study findings suggest oxidative stressful state associated with reduced antioxidant defence potential in erythrocytes of leprosy patients. The study implicates association of erythrocyte oxidative stress with bacterial load and type of leprosy.</p>  a0305-7518