02092nas a2200433   4500000000100000008004100001260001300042653002600055653002000081653001400101653004400115653003800159653005300197653001100250653001600261653002300277653002100300653001200321653002500333653002500358653001400383653002400397653002500421653001700446653002500463100001400488700001100502700001200513700001300525700001600538700001500554700001300569245015500582856004100737300001000778490000700788520084900795022001401644       1991                            d  c1991 Dec10aAntibodies, Bacterial10aCells, Cultured10aCytokines10aDose-Response Relationship, Immunologic10aEnzyme-Linked Immunosorbent Assay10aGranulocyte-Macrophage Colony-Stimulating Factor10aHumans10aImmune Sera10aImmunity, Cellular10aInterferon-gamma10aleprosy10aLeprosy, lepromatous10aLeprosy, Tuberculoid10aMonocytes10aMycobacterium bovis10aMycobacterium leprae10aPhagocytosis10aRecombinant Proteins1 aLaunois P1 aBlum L1 aDieye A1 aMillan J1 aSarthou J L1 aMichel J C1 aBach M A00aM. leprae- and BCG-induced chemiluminescence response of monocytes from leprosy patients and healthy subjects: effects of gamma-interferon and GM-CSF.  uhttp://ila.ilsl.br/pdfs/v59n4a06.pdf  a582-90 v593 a<p>Mycobacterium leprae, in contrast to BCG, failed to trigger any chemiluminescence (CL) response in mononuclear cells from either leprosy patients or healthy subjects, a deficit not reversed by either interferon-gamma or GM-CSF. Chemiluminescence responses induced without mycobacteria or with BCG were found to be lower in leprosy patients than in controls. M. leprae were also less well phagocytosed than BCG. However, there was a significant difference in phagocytosis between healthy and tuberculoid leprosy subjects. Phagocytosis was not altered by the addition of either lymphokine, and no major differences between healthy subjects and patients were observed. Preincubating mononuclear cells with anti-mycobacteria antibodies (lepromatous patients' sera) did not increase the CL response nor the phagocytosis of M. leprae or BCG.</p>
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