02180nas a2200301   4500000000100000008004100001260001300042653001200055653001700067653001100084653003000095653002300125653001200148653002600160653000900186653002400195653002500219653001800244100001300262700001300275700001400288245013300302856004100435300001200476490000700488520136900495022001401864       1991                            d  c1991 Dec10aAnimals10aCyclosporine10aFemale10aHypersensitivity, Delayed10aImmunity, Cellular10aleprosy10aLymphocyte Activation10aMice10aMice, Inbred BALB C10aMycobacterium leprae10aT-Lymphocytes1 aTanaka M1 aTanaka Y1 aKohsaka K00aEffects of cyclosporin A on bacterial growth and immunological responsiveness in BALB/c mice infected with Mycobacterium leprae.  uhttp://ila.ilsl.br/pdfs/v59n4a08.pdf  a598-6040 v593 a<p>When BALB/c mice were infected with Mycobacterium leprae and orally treated 6 times weekly with a dose of 8 mg/kg cyclosporin A (CsA) for 19 months, the number of organisms was slightly higher at 19 months as compared with mice in which the dose of CsA was gradually decreased after 6 months and discontinued at the 8th month (p less than 0.01 for the 15th and 19th months). Lymphocyte blast transformation (LBT) showed that spleen cells from CsA-treated mice 4 weeks after infection with M. leprae and 3 weeks after CsA treatment was stopped responded to the sonicated supernatant of M. leprae suspension (SS), M. leprae (Ml), and concanavalin A (ConA) less than those cells from mice not treated with CsA. This response was dose-dependent. At week 15, 14 weeks after CsA administration was stopped, the LBT response to SS and Ml by cells from M. leprae-infected mice exceeded that of mice without CsA treatment, and the response to ConA in M. leprae-infected mice was less than that in uninfected mice without CsA-treatment. Thus, if CsA was administered, the T-cell functions were suppressed. However, when CsA treatment was discontinued for longer periods, the T-cell function was activated. From these results, we speculate that M. leprae would have the capability of growing more abundantly in mice treated with CsA 100 mg/kg for 1 week every month.</p>
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